- Luteinizing hormone releasing
hormone (LHRH)
- Follicle stimulating hormone
(FSH): FSH stimulates the ovaries and growing follicles
- Luteinizing hormone (LH): LH
stimulates ovulation
- Oestrogen: It is responsible for
regulating and sustaining female sexual development and reproductive
function
- Progesterone: It prepares endometrium
for implantation
How are ovulation and menstruation defined?
- At the beginning of a period, a
hormone called Follicle Stimulating Hormone (FSH) is released from the pituitary
gland. FSH stimulates a follicle on the surface of the ovary to grow.
Contained within the follicle is the developing egg.
- During the next two weeks the egg
grows and matures, and as it does, so a female hormone called oestrogen is
produced in increasing quantities by the ovary. The oestrogen in turn
enters the bloodstream and feeds back to a part of the brain above the
pituitary gland where it is recognized by special receptors. If enough oestrogen
has been produced, this feed back process decreases the production of
FSH.
- Rising oestrogen levels also
trigger the output of another hormone from the pituitary gland called
Luteinizing Hormone (LH). This leads to the release of the mature egg from
the follicle. The escape of the egg from the ovary is known as
ovulation.
- After ovulation, the empty
follicle forms a structure called the corpus luteum, which produces the
second female hormone called progesterone. The progesterone levels go up
after ovulation, and maintain the endometrium in a state of readiness to
receive a fertilized egg. If the fertilized egg does not implant itself
the progesterone level falls and a period commences. The whole cycle now
begins once more.
- Oligomenorrhoea (very
erratic periods): There is a defect in the feedback of oestrogen from
the ovary to the brain. In spite of this, levels of F.S.H., L.H. and oestrogen
are normal, but there is usually a menstrual disorder with either Oligomenorrhoea
or secondary amenorrhoea.
- Amenorrhoea (never have
a period or periods have stopped): The pituitary gland fails to
produce F.S.H. and L.H. This, in turn, affects the ovaries, which fail to
produce oestrogen. Amenorrhoea is usually the representing symptom.
- Menopause-like condition: The ovaries fail to respond or
may be resistant to F.S.H. As is the case in menopause, the F.S.H. levels
are very high and the oestrogen level very low.
- Polycystic Ovary Disease: This is a condition where there
are multiple tiny cysts in the ovaries. The L.H. level is
characteristically high with normal F.S.H. and oestrogen levels. There is
often Oligomenorrhoea or amenorrhoea.
- Hyperprolactinaemia: The level of the hormone prolactin
is very high while the levels of F.S.H. and oestrogen are lowered. This
condition is known as hyperprolactinaemia. There is either Oligomenorrhoea
or amenorrhoea. Discharge from the nipples is also a symptom of this
condition as this is the hormone responsible for milk production.
If you have amenorrhoea, your specialist may recommend a test
called the Progesterone Challenge Test before the commencement of the”fertility drug" treatment. This involves taking progesterone tablets for five days. If the ovaries are producing oestrogen, a withdrawal menstrual bleed should occur after progesterone tablets have been stopped.
- You may never have had a period, a
condition called primary amenorrhoea;
- Periods which were once present
have now stopped altogether (known as secondary amenorrhoea);
- Your cycle is so erratic. E.g.
periods occurring every 1-4 months, that even if you are ovulating,
ovulation is completely unpredictable (known as Oligomenorrhoea).
Ovulation predictor kits are the most convenient method for predicting ovulation. Although slightly expensive, they offer you that luxury of testing in the privacy of your home. They simply require you to collect a few drops of urine and test them on the stick over a period of about 7-10 days of your likely ovulation time. The day the stick changes colour to a shade darker than the previous days, you are likely to ovulate within the next 48 hours. If you have run out of all the sticks in the pack without detecting a colour change, you may have to buy another test kit and continue testing. It could mean that either you have not yet ovulated, or that you may not be ovulating in this cycle.
This method requires the woman to keep a chart of her daily temperature readings. The temperature needs to be taken from the woman is anus first thing in the morning while she is still in bed. It can be recorded using either special test kits available in the market, or a regular thermometer. The basis for this method is that a woman’s basal body temperature drops briefly and then raises half a degree following ovulation, and remains elevated until the start of the next period. Normal BBT is between 96 and 98 degrees, and after ovulation rises to 97 to 98 degrees. A rise in temperature that persists for at least 3 days indicates that ovulation has occurred.
Another method that is more recent depends on the analysis of the vaginal mucus. A few days before, also called the dry period, there is very little mucus in the vagina. When there is white vaginal discharge in the vagina, it indicates the beginning of the wet period. At the time of ovulation, the mucus becomes clear, sticky and stringy in nature, and can sometimes stretch to over a couple of inches between your two fingers.
Another way of determining your ovulation is through an ultrasound scan. An ultrasound scan is also usually used when it is critical for fertilization to take place at the precise time of ovulation, such as for artificial insemination. This method of predicting ovulation, although very reliable, is quite expensive.
The pre-ovulatory phase is the time between menstruation and ovulation. During the first few days after the beginning of menstruation, concentrations of FSH & LH increase several fold. These hormones cause accelerated growth of 6-12 primary follicles each month. When under the influence of FSH, the group of follicles continue to grow and secrete oestrogen. One dominant follicle becomes mature graafian follicle i.e. continues to increase its oestrogen production under the influence of increasing level of LH. Small amounts of progesterone are produced by the mature follicle a day or two before ovulation.
Estrogens liberated stimulate repair of endometrium and thicken it. New ovulation occurs on the 14th day i.e. there is rupture of mature graafian follicle. Post ovulatory is the period between ovulation and next menses. A single ovum is expelled from an ovarian follicle into the abdominal cavity in the middle of each monthly cycle. This ovum then passes through one of the fallopian tubes into the uterus and if it is fertilized by a sperm, it implants in the uterus where it develops into a fetus.
If fertilization does not take place, this ovum gets released in the menstrual phase. During the menstrual phase, follicles in each ovary begin to enlarge. Menstrual flow from the uterus consist of 50-150ml blood, tissue fluid, epithelial cells derived from endometrium.
- Ovulation is essential;
- Intercourse must take place during
the fertile phase of the cycle;
- Your partner's sperm count must be
adequate to ensure that a sufficient number actually reach the egg;
- The mucus in the cervix must not
be unfavourable and/or hostile to the sperm;
These methods are based on the principle that conception can be avoided by abstaining from sex during the woman's most fertile period. The two most popular methods are the temperature method and the rhythm method. These have a very high success rate when combined with other forms of contraception.
These methods mechanically block the sperm from entering the uterus. These include condoms, diaphragms (soft rubber cup-like devices used with sperm-killing cream, inserted into the woman's vagina before intercourse), intrauterine devices or IUDs (inserted into the woman's vagina and kept there for the entire time she does not wish to conceive), vaginal insert contraceptives, etc. In addition to contraception, the advantage of these barrier methods is that they prevent the spread of AIDS and other sexually transmitted diseases.
Creams, foams, jelly and similar substances with special spermicidal chemicals can be useful contraceptives. These substances are inserted into the vagina before intercourse, and essentially immobilize the sperms and make them ineffective.
Birth control pills are specially designed to control the hormone levels of the woman. These pills need to be taken daily, for the entire duration that the woman is sexually active and does not wish to conceive. If taken correctly, success rate is close to 100%, but the drawback is that one needs to remember to take it daily; else it loses its effectiveness.
Rhythm method
|
80% on average
|
Foam
|
80% on average
|
Diaphragm
|
85% on average
|
Condom
|
90% on average
|
Combination pill
|
97% on average
|
IUD
|
99%
|
- Mild side effects: Nausea, weight gain (about 2
kgs), fluid retention, breast tenderness, spotting between periods.
These side effects usually subside in the first three months
- Moderately serious side effects: Breast pain, discharge or
engorgement; rash, itching or jaundice; reduced tolerance to contact
lenses; headaches or migraines; nervousness or depression. If you
experience any of these side effects, you should inform your doctor.
The doctor may be able to prescribe another brand of the birth control
pill that may be more suitable for you. He may also ask you to stop the
pills completely and resort to a different form of contraception.
- Serious side effects: Blood clots are a serious side
effect of the pill. Blood clots will exhibit different symptoms
depending on the part of the body where they form. Some of these
symptoms are leg tenderness or swelling; sudden chest pain or shortness of
breath, partial or complete loss of vision or blackouts; numbness in any
part of the body. If you experience any of these symptoms, you
should immediately stop the pill and consult your doctor.
For whom is the birth control pill not advisable?
- Women over 35 who smoke;
- Women with high blood pressure,
high cholesterol, or a family history of heart disease;
- Women with past or present breast,
uterus or liver cancer;
- If a pregnancy is suspected
- No loss of natural feeling when
compared to condoms.
- No side effects such as vomiting,
headaches and weight gain when compared to oral pills.
- No bleeding or pain when compared
to the Loop.
- No interference of a third party
because it is do-it-yourself method.
- Injectable contraceptives are used as a temporary method of contraception by females. They have been in use in India since 1992.
- They are widely accepted in USA, Europe and parts of Asia, especially in Thailand and Indonesia.
- Injectable Contraceptives (ICs) are made up of progestational compounds. Progesterone is one of the female sex hormones. This hormone is normally present in healthy, adult women during the latter half of their menstrual cycle.
- Noristerat (Chemical name -
Norethindrone Enanthate, also called Net-en)
Noristert is to be given every 2 months. - Depo Provera (Chemical name -
Medroxyprogesterone acetate)
Depo Provera is to be given every 3 months.
Both are available as single dose ampules. Either of the two can be used. The choice is yours or your gynaec's!
They have a 99% rate of efficacy during the first year of use, and are thus very effective.
- Their effect is rapid. They start
working within 24 hours after administration.
- A pelvic examination is not
required prior to use.
- They do not interfere with intercourse.
- They do not affect breast-feeding.
They can be given to lactating women without any effect on the baby or on
the amount of breast milk.
- They have minimal side effects.
There is no nausea, rise in blood pressure or any clotting disorder
associated with their use. In fact, these risks are associated with oral
pills. However, cases of mild headaches or dizziness should be reported to
the doctor.
- They provide you with protection
for 2 to 3 months. There is no need to use any other form of contraception
during this period.
- Unusual discharge from the
vagina
- Pain, burning or itching around
the vagina
- Pain in the pelvic area or
abdomen, sometimes with fever or chills
- Bleeding other than your usual
period
- Sores or blisters on the genitals
or in the mouth
In the case of men, the following symptoms could indicate that they have contracted a STD:
- Discharge from the end of the
penis
- Pain or burning when
urinating
- Swelling around the groin
- Sores or blisters on the genitals
or in the mouth
- Flu-like symptoms such as fever
chills, aches in the joints or muscles
B. Other non-contraceptive benefits
May decrease menstrual cramps.
- May decrease menstrual bleeding.
- May improve anaemia.
- Protects against some causes of
pelvic inflammatory diseases.
- Decreases chances of ectopic
pregnancy.
- Decreases benign breast disease.
- Protects against endometrial
cancer.
- Any nurse or trained non-medical
staff can administer the injection. There is no need to book an
appointment with your gynaec every time you need a shot.
DISADVANTAGES
- Menstrual Irregularities -
Spotting, breakthrough bleeding and sometimes skipping of your periods are
the side effects of these contraceptives. However, skipping of your
periods is natural when you are on the IC and it does not cause any harm…
and, of course, it helps in cases of anaemia!
- Planning or postponement of the
period is not possible when the woman is on ICs.
- One cannot accurately predict the
timing of the period, which may create a slight problem, especially when
planning a holiday or even religious function.
- There may be a delay in return to
fertility after discontinuing ICs. Pregnancy may not occur immediately. On
an average it takes 2-3 months after you stop taking the pill or removing
a Copper T to resume fertility. If you are using injectable contraception,
this period is longer, and can be 4 to 5 months.
- ICs do not provide protection
against STDs or HIV. Neither do oral pills for that matter. Only condoms
or any other barrier method of contraception can provide this
protection.
- Buy your own condoms and don't
forget to check the expiry date. And this applies to women too. Remember
that your body is your responsibility. It is up to you to look out for
yourself and take the necessary precautions.
- Make sure that you or your partner
knows how to use a condom properly and use it every time you have sex.
- You are not going to be in a
condition to make a sensible decision about safer sex under the influence
of alcohol or drugs. Make your stand clear to your partner before you
indulge yourself in these substances.
- Promiscuity could mean trouble. Be
picky about your sexual partners and try to avoid having intercourse with
people who have multiple partners.
- Birth control pills, diaphragms or
IUDs do not provide adequate protection against STDs. Spermicides provide
a small degree of protection against STDs, but it is advisable to use them
in combination with other methods of protection.
- Keep yourself informed about the
symptoms of different STDs so that you can check with the doctor if you
have the slightest suspicion that you have contracted a STD.
- If you are sexually active, it is
a good idea to routinely check for STDS even if you don't have any
symptoms.
- Tell your partner if you have been
diagnosed as having a STD so that he or she can get tested.
- If you or your partner have been
infected with a STD, you will have to abstain from sex.
- Don't let any feelings of
embarrassment stand in the way of your visiting the doctor if you suspect
that you may have contracted a STD.
What to expect at the doctor's clinic
The lady on the phone sounded really frantic. It was the principal of a well-reputed English medium school. Ever since a series of articles on AIDS had been run in the local newspapers, she and the biology teacher of the school had been inundated with questions from the students. And they found to their horror that most of the facts about the subject were unclear to them too. A simple one-hour affair explaining the basics of the condition so that all confusion was clear, once and for all. She also wanted a question and answer session following the deliberations.
The condition of AIDS could not have been more aptly named.
After the virus enters the blood stream (known as exposure in medical parlance), in almost all cases a fixed sequence of events occurs (see Box-II). A virus coming in contact / or deposited on intact skin / mucous membrane - poses no danger. But even if there is a micro abrasion (often unseen by the naked eye), the risk increases dramatically.
Unlike many medical conditions where certain typical features characterise a particular disease, AIDS is completely different. AIDS by itself does not have any peculiar symptoms - but depending on the organ system involved it can present itself in numerous garbs. (Hence the question what are the symptoms of AIDS? is technically a wrong question).
Apart from the general diseases that affect any normal individual, HIV patients often are susceptible to a group of infections called Opportunistic infections.
Especially in India, it’s usually a drug resistant and widespread TB and severe diarrhoea, which have been most frequently seen, in HIV positive cases. In the US, it is pneumonia (a rare variety of it), which is the most common clinical presentation. And finally in Africa severe diarrhoea is the most common symptom, which is also known as the Slim disease because of the acute weight loss it causes. Though certain findings mentioned earlier can lead one to suspect HIV infection, some tests are necessary to confirm the diagnosis.
Sexual Intercourse (Vaginal/Anal)
|
0.1 % - 1.0 % (male to female is 7-
10 times more than female to male) Having STD increases the risk.
|
Blood Transfusion
|
90 - 95 %
|
Pregnant Mother to Child
|
20 - 40 %
|
Intravenous Drug Abuse & Others
(*)
|
0.5 - 1.0 %
|
Breast Milk
|
Controversial (but if present,
benefits definitely outweigh risks)
|
Saliva
|
Controversial (just anecdotal reports
till now been presented in its favour).
|
- Casual contact (sitting together,
sharing clothes/ utensils).
- Casual kissing, shaking hands
(deep kissing when there are oral ulcers could be risky).
- Mosquitoes
- Swimming Pools/ Door knobs/
Railings/ Toilet Seats
- Donating blood
Infection (exposure)
|
Sexual Intercourse. Blood
transfusion, Intravenous drug abuse, Mother to unborn child.
|
Influenza like illness
|
2 - 3 weeks after infection (fever,
fatigue, rash). Subsides on its own, often without the patient noticing it.
So transient it is that the very occurrence of this is being doubted.
|
Seroconversion
|
6 - 12 weeks. HIV test now becomes
positive. Patient absolutely fit and normal. Till this stage only the most
advanced tests can help diagnose AIDS. (This period can be as long as 6
months also
|
Enlargement of lymph nodes. AIDS
related complex (weight loss, fever, diarrhoea, oral ulcers, and herpes).
|
Depending on the patients own
immunity and how severe the initial infection is, these related stages come
at roughly around 5 years (but this is variable - a long period if infection
is through intercourse and short if by blood transfusion)
|
AIDS (Symptomatic HIV)
|
20 % of those infected develop it in
5 years and 50 % in 10 years. Till this stage the patient is merely HIV
positive. AIDS is labelled when the patient
has I) Opportunistic Infections ii)
A malignancy called Kaposi’s Sarcoma and iii) some neurological deficit.
After this the patient soon succumbs. (See Note � 6.)
|
- A patient is infectious to others
right from the moment of infection. A receiver can /may manifest symptoms
much earlier than one who hands over the infection.
- Infection can only occur,
(essentially) if the viruses enter the blood stream and not merely surface
contact.
- Only recently has it been
confirmed that a few cases despite being HIV positive 13- 14 years ago
have not as yet developed AIDS.
- There have been reports of some Caws/ patients not acquiring AIDS despite continuous
exposure to the virus. [Active research is going on this direction also,
as to why are some persons naturally resistant to HIV]
- Doubtful reports talk of
spontaneous reversal of HIV status.
- Present terminology is symptomatic
HIV (i.e. AIDS is now more properly called Symptomatic HIV) and
asymptomatic HIV. Terms like AIDS or full-blown AIDS are no longer in
vogue.
Symptoms can be in the form of any
single or multiple system involvement. Infection occurs which either does not
respond to routine treatment because of resistant strains or, if it responds,
it does so after a long time only to recur. Such repeated infections
debilitate the body leading to death. The drugs too, often produce rare
reactions in AIDS patients not commonly seen otherwise. Some of the commonly
encountered symptoms in HIV positive patients would be as follows.
RESPIRATORY |
GASTROINTESTINAL
|
NERVOUS
|
SKIN
|
|
|
|
|
Cough
|
Persistent diarrhoea (by common and
rare pathogens)
|
Headache
|
Xerosis (Dry Skin)
|
Breathlessness
|
Difficulty in swallowing or eating
|
Altered Personality
|
Purpuric Spots
|
Rapid Breathing
|
Perianal discomfort
|
Lethargy
|
Hair loss/ Greying of hair
|
Blood stained cough
|
|
Dementia
|
|
Effusions in Lung cavity
|
|
Convulsions
|
Bacterial Viral infections
Fungal |
|
|
Meningitis
|
|
|
|
Visual Impairment
|
|
A) Few of these could be
a)Recurrent/ widespread Herpes Zoster
b)Oesophageal Candidacies
c)Kaposi’s Sarcoma in a young person
d)Oral Hairy Leucoplakia
(Especially for those with high-risk behaviour)
- RELAX. DONT PANIC
- Get an ELIZA test done at a
laboratory after 12- 14 weeks of the suspected exposure. In an Indian
set-up nothing can help diagnose AIDS before this. Meanwhile assuming that
you are infected takes care and do not infect others. (E.g. No blood
donation, no unprotected intercourse, no pregnancy).
- If the test is negative - learn a
lesson not to repeat the mistake.
- If positive - get a repeat test
done and if possible a Western blots.
- If Western blot too is positive,
not everything is lost. Get professional help at counselling centres.
Contact the nearest Government hospital. Get advice as to the drug therapy
to be started.
- Lead a regular, hygienic and a fit
lifestyle. [Healthy nutritious food, no vices]. Avoid stress. In short,
avoid anything that can lead to an infection affecting the body. On the
other hand, anything that boosts the body's general immunity helps.
- Yoga, Relaxation, Meditation are
said to help a lot.
- Conquer fear.
- Anal Intercourse
- Drug addiction
- Patient of STD's
- Blood Transfusion Recipients
- As with all viral infections HIV too has a very small armamentarium of drugs against it. Since viruses multiply within living human cells, drugs to act on them, have to damage the human cell as well.
- Viruses being extremely small and having a very simple structure, drugs have a few sites to act on (unlike as in bacteria, where they can act on the cell wall, the nucleus, the cytoplasm, the organelles etc.) to disable them.
- As for the vaccines, they help us fight diseases by acting on the immune system. Unfortunately in AIDS it is this immune system itself, which is under attack. Secondly, the virus (like the common cold virus) is known to alter its structure when inside the body thereby rendering the vaccine useless. This is so because the vaccine is very specific and only on a fixed and similar structure. Even a minute change renders the vaccine ineffective. Naturally it is difficult to synthesise vaccines against all the structural variations.
(What all should you do, so as not to get infected)
- Avoid sex with multiple
partners or even with a single partner who in turn has multiple partners
(ideally speaking stick to one single, absolutely faithful partner).
- If sex is unavoidable, always wear
a condom (though there is no guarantee, at least this offers the best
protection) - e.g. during sex with a Community Sex worker. Other methods
of contraception provide NO protection.
- Avoid unnatural modes of sex
(anal/ oral)
- Avoid intravenous drug abuse - and
if unavoidable at least don’t share needles and syringes you can use disposable ones.
- Take blood transfusions, only when
you must and that too from a blood relative / friend and after getting it
thoroughly tested.
- Pettings, Masturbation, Mutual
Masturbation are the safest alternatives to sex.
- Insist that your barber use a
fresh blade every time he shaves / cuts your hair.
- Always insist on disposable
needles and syringes when taking shots.
- Contact your local AIDS
Counselling Centre / Government hospitals for any further clarifications.
- Remember even a single act of
unprotected intercourse (forget the complete act, even unprotected
penetration without going the whole way) with an infected partner can lead
to infection.
- Active research is going on at
such a rapid rate that a few of the concepts (true at the time of going to
print) might turn out to be invalid in days / months to come.
- The write-up is an extremely
simplified picture of the very complex disease process. The above stated
points are accepted by the majority. However not all doctors/ specialists
might be in agreement with all the points.
- Try to avoid stressful situations
and get some rest.
- Mild exercise like walking can
help relieve PMS.
- Control the intake of alcohol and
caffeine contained in tea, coffee, soft drinks, etc.
- Reduce salt intake. Salt absorbs
water and increases water retention.
- Vitamin B6 also helps in reducing
premenstrual tension and water retention.
- Eat less at every meal, but more
often. This will minimize the fluctuations in blood sugar. It may also
help to eat more green leafy vegetables, whole grains and cereals, fish
and poultry.